柳叶刀子刊：不明原因儿童急性肝炎，或与新冠病毒超级...
<div style="max-width:100%;overflow:hidden;"><p data-mpa-powered-by="yiban.io" style="margin-right: 8px;margin-bottom: 0em;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;visibility: visible;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;font-size: 15px;visibility: visible;box-sizing: border-box !important;overflow-wrap: break-word !important;"><br></span></p><p data-mpa-powered-by="yiban.io" style="margin-right: 8px;margin-bottom: 0em;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;visibility: visible;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;font-size: 15px;visibility: visible;box-sizing: border-box !important;overflow-wrap: break-word !important;"> 最近，英国、欧盟、美国、以色列和日本等地都报告了至少348例儿童不明原因严重急性肝炎。大多数患儿早期出现胃肠道症状，随后发展为黄疸，在某些情况下还会出现急性肝功能衰竭。令科学家困惑的是，这些患儿中未发现甲型、乙型、丙型、丁型和戊型肝炎病毒。</span></p><p style="margin-right: 8px;margin-bottom: 0em;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;visibility: visible;box-sizing: border-box !important;overflow-wrap: break-word !important;"><br style="outline: 0px;max-width: 100%;visibility: visible;box-sizing: border-box !important;overflow-wrap: break-word !important;"></p><p style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;visibility: visible;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;font-size: 15px;visibility: visible;box-sizing: border-box !important;overflow-wrap: break-word !important;">目前的数字可能只是冰山一角，因为许多国家刚开始加强对这种不明原因儿童急性肝炎病例的监测。</span></p><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;visibility: visible;box-sizing: border-box !important;overflow-wrap: break-word !important;"><br style="outline: 0px;max-width: 100%;visibility: visible;box-sizing: border-box !important;overflow-wrap: break-word !important;"></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;visibility: visible;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;letter-spacing: normal;visibility: visible;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;font-size: 15px;visibility: visible;box-sizing: border-box !important;overflow-wrap: break-word !important;">英国是此次报告不明原因儿童急性肝炎病例最多的国家。英国卫生安全局</span><span style="outline: 0px;max-width: 100%;font-size: 15px;color: rgb(136, 136, 136);visibility: visible;box-sizing: border-box !important;overflow-wrap: break-word !important;">（UKHSA）</span><span style="outline: 0px;max-width: 100%;font-size: 15px;visibility: visible;box-sizing: border-box !important;overflow-wrap: break-word !important;">的调查信息显示：所有的患儿都进行了新冠的核酸检测，然而大部分患儿却没做血清学新冠检测。</span></span><span style="outline: 0px;max-width: 100%;font-size: 15px;visibility: visible;box-sizing: border-box !important;overflow-wrap: break-word !important;"></span><br style="outline: 0px;max-width: 100%;visibility: visible;box-sizing: border-box !important;overflow-wrap: break-word !important;"></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;visibility: visible;box-sizing: border-box !important;overflow-wrap: break-word !important;"><br></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;visibility: visible;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;visibility: visible;box-sizing: border-box !important;overflow-wrap: break-word !important;">是什么导致了全球二十多个国家和地区的三百多例不明原因儿童急性肝炎？</span></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;visibility: visible;box-sizing: border-box !important;overflow-wrap: break-word !important;"><br></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;visibility: visible;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;visibility: visible;box-sizing: border-box !important;overflow-wrap: break-word !important;">2022年5月13日，《柳叶刀》子刊《柳叶刀·胃肠病和肝病学》</span><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;color: rgb(136, 136, 136);visibility: visible;box-sizing: border-box !important;overflow-wrap: break-word !important;">（The Lancet Gastroenterology ＆ Hepatology）</span><span style="outline: 0px;max-width: 100%;letter-spacing: normal;font-size: 15px;visibility: visible;box-sizing: border-box !important;overflow-wrap: break-word !important;">上发表的一项最新文章认为，</span><span style="outline: 0px;max-width: 100%;color: rgb(217, 33, 66);visibility: visible;box-sizing: border-box !important;overflow-wrap: break-word !important;"><strong style="outline: 0px;max-width: 100%;visibility: visible;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;letter-spacing: normal;font-size: 15px;visibility: visible;box-sizing: border-box !important;overflow-wrap: break-word !important;">这可能</span><span style="outline: 0px;max-width: 100%;font-size: 15px;visibility: visible;box-sizing: border-box !important;overflow-wrap: break-word !important;">与新冠病毒导致的超级抗原相关。</span></strong></span></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;visibility: visible;box-sizing: border-box !important;overflow-wrap: break-word !important;"><br></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;visibility: visible;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;color: rgb(217, 33, 66);visibility: visible;box-sizing: border-box !important;overflow-wrap: break-word !important;"><strong style="outline: 0px;max-width: 100%;visibility: visible;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;font-size: 15px;visibility: visible;box-sizing: border-box !important;overflow-wrap: break-word !important;"></span></strong></span></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;visibility: visible;box-sizing: border-box !important;overflow-wrap: break-word !important;"><br style="outline: 0px;max-width: 100%;visibility: visible;box-sizing: border-box !important;overflow-wrap: break-word !important;"></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;visibility: visible;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;visibility: visible;box-sizing: border-box !important;overflow-wrap: break-word !important;">文章作者为伦敦帝国理工学院免疫学和炎症系教授 <strong style="outline: 0px;max-width: 100%;visibility: visible;box-sizing: border-box !important;overflow-wrap: break-word !important;">Petter Brodin</strong> 和美国加利福尼亚州洛杉矶 Cedars Sinai 医疗中心儿科、传染病和免疫学部的 <strong style="outline: 0px;max-width: 100%;visibility: visible;box-sizing: border-box !important;overflow-wrap: break-word !important;">Moshe Arditi</strong>。</span></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;visibility: visible;box-sizing: border-box !important;overflow-wrap: break-word !important;"><br></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;text-align: center;visibility: visible;box-sizing: border-box !important;overflow-wrap: break-word !important;"><strong style="outline: 0px;max-width: 100%;visibility: visible;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;color: rgb(2, 30, 170);visibility: visible;box-sizing: border-box !important;overflow-wrap: break-word !important;">什么是超级抗原</span></strong></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><br></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;">前述研究表示，儿童感染新冠病毒可导致体内病毒库形成。具体来说是新冠病毒在儿童胃肠道中的持续存在可导致病毒蛋白在肠道上皮细胞中反复释放，从而引起免疫激活。这种反复的免疫激活可能是由新冠病毒的刺突蛋白中超抗原基序介导的，该基序与葡萄球菌肠毒素B相似，能触发广泛和非特异性的T细胞激活。这种超抗原介导的免疫细胞激活已被认为是引起儿童多系统炎症综合征</span><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;color: rgb(136, 136, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;">（Multisystem Inflammatory Syndrome in Children, MIS-C）</span><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;">机制。</span></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><br></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;">所谓超级抗原</span><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;color: rgb(136, 136, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;">（super antigen，SAg）</span><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;">是一类只需极低浓度</span><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;color: rgb(136, 136, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;">（≤10的-9次M）</span><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;">即可激活大量的T细胞克隆、产生极强免疫应答的物质。超抗原与普通抗原相比，不需要常规的细胞内抗原提呈，无MHC限制性。</span></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><br></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;">超级抗原按照活化细胞的不同，可分为T细胞超级抗原和B细胞超级抗原，又按照其来源不同分别将T、B细胞超级抗原分为内源性</span><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;color: rgb(136, 136, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;">（病毒型）</span><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;">超抗原和外源性</span><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;color: rgb(136, 136, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;">（细菌型）</span><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;">超抗原。</span></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><br></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;">儿童多系统炎症综合征最早于2020年4月开始被广泛关注。彼时，全球刚刚进入新冠大流行，多个国家便陆续报道一种“儿童怪病”，并且和新冠病毒感染高度相关，多数患者出现发烧、皮疹、呕吐、颈部淋巴肿大、嘴唇干裂和腹泻等症状，与川崎病症状相似，也被称为类川崎病。</span></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><br></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;">儿童多系统炎症综合征多发生在新冠感染2-6周之后，发病患儿年龄集中在3-10岁间。儿童多系统炎症综合征与川崎病表现不同，在血清监测新冠阳性儿童中病情更为严重。儿童多系统炎症综合征能引起包括心脏、肺、肾脏、大脑、皮肤、眼睛或肠胃、肝脏等多器官炎症，严重的会导致多器官衰竭，进而导致患儿死亡。</span></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><br></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;">研究团队表示，<strong style="outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;">在此前的儿童多系统炎症综合征中也曾报道过急性肝炎，但未调查其他病毒的合并感染</strong>。研究者分析称，最近的不明原因儿童急性肝炎可能是先感染了新冠病毒，患儿在肠道中出现了病毒库后又感染了腺病毒。</span></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><br></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;">具体来说，如下图所示</span></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><br></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;"></span></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;letter-spacing: normal;color: rgb(136, 136, 136);font-size: 13px;box-sizing: border-box !important;overflow-wrap: break-word !important;">腺病毒（AdV）增强新冠病毒超级抗原介导的严重急性肝炎的病理学示意图</span></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><br></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;">在感染新冠病毒后，病毒库可能会随着时间的推移导致反复的超级抗原介导的免疫细胞激活，如多系统炎症综合征</span><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;color: rgb(136, 136, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;">（MIS-C）</span><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;">。如果存在此类病毒库，并且儿童随后感染了腺病毒</span><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;color: rgb(136, 136, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;">（AdV）</span><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;">，这种超抗原介导的影响可能会更加明显，并可能导致免疫异常，如最近报告的急性重度肝炎，这就是为什么在这些病例中应该调查这种免疫病理学的证据。</span></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><br></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;">研究者报告了小鼠实验中的类似情形：腺病毒感染激发葡萄球菌肠毒素B介导的中毒性休克，导致小鼠肝功能衰竭、死亡。这一结果可以通过腺病毒诱导的1型免疫偏移来解释，在随后的葡萄球菌肠毒素B给药后导致过量的IFN-γ产生和IFN-γ介导的肝细胞凋亡。</span></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><br></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;">Brodin表示，根据目前的情况，建议对出现急性肝炎的儿童的粪便进行持续的新冠病毒监测，并调查患儿的T细胞受体偏移和IFN-γ上调，因为这可以提供新冠病毒超抗原的证据以及腺病毒41F敏感宿主的机制。如果发现新冠病毒超级抗原介导的免疫激活的证据，则应考虑对患有严重急性肝炎的儿童进行免疫调节治疗。</span></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><br></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;"><strong style="outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;color: rgb(2, 30, 170);box-sizing: border-box !important;overflow-wrap: break-word !important;">仅腺病毒不足以引发健康儿童出现急性肝炎</span></strong></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><br></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;">英国是此次报告不明原因儿童急性肝炎病例最多的国家。英国卫生安全局</span><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;color: rgb(136, 136, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;">（UKHSA）</span><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;">的调查信息显示：所有的患儿都进行了新冠的核酸检测，然而大部分患儿却没做血清学新冠检测。</span></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><br></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;">值得注意的是，核酸检测只能确定患儿当时是否感染了新冠，而要看过往是否感染过新冠，则需要靠血清学检测。患儿还接受了腺病毒的全血检测。不过大部分患儿未做肝脏的活检。</span></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><br></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;">在缺乏关键信息的情况下，英国卫生安全局便提出了以腺病毒为第一位的致病假说。英国卫生安全局还表示，英国的疫情防控可能造成部分幼儿与常见病原体的接触减少，导致其免疫系统的发育不同于新冠疫情前的同龄儿童，于是患儿被腺病毒轻而易举地击倒了。</span></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><br></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;">该假说受到了医生和病毒学家的广泛质疑。其中的两大疑点：第一，为何英国患儿肝脏的活检没有发现腺病毒的包涵体；第二，患儿的腺病毒载量为何如此低，病毒样本都不足以做腺病毒全基因组检测。</span></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><br></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;">对于英国目前披露的信息，瑞士日内瓦大学新发传染病中心负责人<strong style="outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;"> Isabella Eckerle </strong>近日表示，患有急性肝炎的儿童肝活检中未检测到腺病毒。如果是腺病毒导致的，则肝脏应该有腺病毒相关的病理学体现。</span></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><br></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;">伦敦玛丽女王大学流行病学家 <strong style="outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;">Deepti Gurdasani </strong>也表示，英国目前还没有一名患儿肝脏活检显示存在腺病毒包涵体。如果腺病毒导致急性肝炎的假说成立，这是最基本的要求。所谓包涵体，是指病毒感染宿主细胞后在细胞内所形成的在光学显微镜下可见的小体。</span></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><br></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;">内科医生、加州大学欧文分校博士 <strong style="outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;">Farid Jalali </strong>表示，对健康的儿童、成人来说，腺病毒一般是自限性疾病，会导致呼吸道、肠胃或者结膜炎症。但要严重到可以导致急性肝功能衰竭甚至死亡的情况，在免疫力正常人群中从未见到。这种情形发生在免疫力严重缺陷人群中，比如接受器官移植、化疗的人。</span></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><br></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;"><strong style="outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;">Isabella Eckerle </strong>质疑，即使英国卫生安全局提出的血液样本中检测到腺病毒，也有一个问题就是血液中的病毒载量很低。在某些病例中，患者的腺病毒DNA仅存在于全血中，而不存在于血浆中。“如果是腺病毒导致的急性肝炎，那么在肝脏中复制的病毒应该随处可见：血浆、血清、活检中都有，而不是大部分患儿只在全血中能检测到。”</span></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><br></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;">事实上患儿的腺病毒Ct值都比较高，意味着病毒载量相对较低。<strong style="outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;">Isabella Eckerle </strong>说这也就是为何只有部分患儿能够对腺病毒进行腺病毒基因片段检测，查出是腺病毒41型。而没有一例的病毒载量高到足以做腺病毒全基因组检测。</span></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><br></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;">对此，<strong style="outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;">Isabella Eckerle </strong>非常疑惑：通常导致肝炎的病毒大量存在于血液中。甲型、乙型、戊型肝炎病毒引发性临床肝炎时，病毒载量非常高：丙型肝炎的情况相对不同，但患儿都已排除丙肝病毒的可能了。其他具有肝嗜性的病毒</span><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;color: rgb(136, 136, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;">（例如黄热病）</span><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;">，也是病毒载量很高。临床表现明显但病毒载量低的病毒性肝炎不存在。</span></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><br></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;">“从我作为临床病毒学家的角度来看，有许多方面反对腺病毒导致急性肝炎的原因。”<strong style="outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;">Isabella Eckerle </strong>说，这对治疗具有重要意义。为什么？这意味着到底应该用抗病毒疗法还是免疫抑制疗法</span><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;color: rgb(136, 136, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;">（例如皮质醇）</span><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;">，这两种疗法会对患者的临床结局带来截然不同的影响。</span></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><br></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;"></span></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><br style="outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;"></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;">可查资料显示，就以这次被高度怀疑的腺病毒41型而言，多导致肠胃炎，其主要组织嗜性是肠胃道，而不是肝脏。</span></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><br></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;">在没有显示任何异常的腺病毒41型完整基因组的情况下，<strong style="outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;">Isabella Eckerle </strong>表示很难相信这种病毒会突然完全改变嗜性，在免疫能力正常的儿童中引起严重的肝脏疾病，这是以前从未观察到的。</span></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><br></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><br style="outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;"></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;"><strong style="outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;">Farid Jalali </strong>表示，健康儿童身上发现腺病毒并不罕见。30%的健康儿童在感染了腺病毒后，病毒在其体内可以存在数月甚至数年。多达11%的健康儿童在其扁桃体、腺样体中能持续检测到腺病毒。可查资料显示，就以这次被高度怀疑的腺病毒41型而言，多导致肠胃炎，其主要组织嗜性是肠胃道，而不是肝脏。<strong style="outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;">Isabella Eckerle </strong>认为，目前不能排除感染新冠后导致儿童出现急性肝炎的可能性。</span></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><br></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;"><strong style="outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;color: rgb(2, 30, 170);box-sizing: border-box !important;overflow-wrap: break-word !important;">新冠血清学检测显示患儿73.7%感染过新冠</span></strong></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><br></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;">相比英国检测的草率，以色列对患儿进行了新冠血清学调查。结果显示大部分都感染过新冠。</span></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><br></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;">据以色列《国土报》《耶路撒冷邮报》报道，该国近期出现12例不明儿童肝炎病例。施耐德儿童医疗中心报告7例，沙雷泽德克医疗中心报告5例。上述病例来自全国不同地点，没有呈现出聚集性感染的特点。其主要症状为严重的肝脏感染和肝酶显著升高，通常伴有黄疸，部分病例出现消化道症状。目前，这些病例均已出院，其中施耐德儿童医院的2个病例因肝功能衰竭实施肝移植，其余病例在接受类固醇药物治疗后迅速好转。</span></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><br></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;">在以色列发现的12例病例中，有11人曾在一年内感染过新冠病毒。尽管没有明确证据表明这种不明肝炎与新冠病毒相关，但多名以色列医疗专家在接受媒体采访时表示怀疑两者间存在联系。施耐德儿童医疗中心小儿肝移植中心主任格拉斯伯格称，在排除了各种可能性之后，发现的所有病例的共同点都是在肝炎出现前三个半月左右感染了新冠病毒。已知严重的新冠病毒感染可能会损害肝脏，因此这种不明肝炎可能是新冠肺炎的长期症状之一。</span></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><br></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;">世卫组织欧洲区域办事处在5月13日报告了该区域16岁及以下儿童的不明原因急性肝炎病例情况也显示超过七成曾感染过新冠病毒。</span></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><br></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;">报告显示欧洲共有14个国家229名儿童出现急性不明原因肝炎，分别是比利时12例、塞浦路斯2例、丹麦 6例、希腊2例、爱尔兰6例、意大利24例、荷兰6例、挪威5例、波兰1例、塞尔维亚1例、斯洛文尼亚 1例、西班牙26例、瑞典9例和英国131例。</span></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><br></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;">75.9%的病例年龄小于5岁。在有相关医疗进展信息的143例中，22例正在重症监护室中，比例达到15.4%。有移植相关信息的98例中有6例接受了肝移植，达到了6.1%。1人已死亡。</span></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><br></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;">有151名患儿接受了所有样本的腺病毒检测，其中90例检测呈阳性，占比为59.6%。其中，全血标本阳性率最高，为68.9%。</span></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><br></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;">173名患儿接受了新冠病毒核酸检测，20例呈阳性，占比为11.6%。仅有19名患儿做了新冠病毒的血清学检验，其中14 人阳性，比例高达73.7%。在有COVID-19疫苗接种数据的56例病例中，47例</span><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;color: rgb(136, 136, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;">（83.9%）</span><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;">未接种疫苗。</span></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><br></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;">事实上，随着奥密克戎变异株在全球带来的新冠大流行，海外已有大量儿童感染过新冠。根据 <strong style="outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;">Nature </strong>的报告，截至2022年2月，美国1-4岁儿童的新冠抗体阳性已接近七成。1-4岁儿童大多未接种疫苗，因此抗体阳性大概率为感染新冠导致的。</span></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><br></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;font-size: 15px;letter-spacing: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;"><strong style="outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;">Isabella Eckerle </strong>担忧地表示，让像新冠这样的新病毒在儿童人群中不受控制地传播，尤其是幼儿大部分未接种疫苗，而且人们对于新冠的长期后遗症研究尚未清楚的情况下，这种放任感染是非常危险的想法。</span></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;"><br style="outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;"></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;text-align: left;box-sizing: border-box !important;overflow-wrap: break-word !important;"><strong style="outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;color: rgb(136, 136, 136);font-size: 12px;box-sizing: border-box !important;overflow-wrap: break-word !important;">论文链接</span></strong><span style="outline: 0px;max-width: 100%;color: rgb(136, 136, 136);font-size: 12px;box-sizing: border-box !important;overflow-wrap: break-word !important;">：</span></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;text-align: left;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;color: rgb(136, 136, 136);font-size: 12px;box-sizing: border-box !important;overflow-wrap: break-word !important;">https://www.thelancet.com/journals/langas/article/PIIS2468-1253(22)00166-2/fulltext</span></section><section style="margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;text-align: left;box-sizing: border-box !important;overflow-wrap: break-word !important;"><span style="outline: 0px;max-width: 100%;color: rgb(136, 136, 136);font-size: 12px;box-sizing: border-box !important;overflow-wrap: break-word !important;"><br></span></section><section class="channels_iframe_wrp"><mpvideosnap class="js_uneditable custom_select_card channels_iframe videosnap_video_iframe" data-pluginname="videosnap" data-id="export/UzFfAgtgekIEAQAAAAAAE6UpMG4hKwAAAAstQy6ubaLX4KHWvLEZgBPEzKJgV1BzM9WDzNPgMIsdCMH4GhPt1Hgkk3s1UgWU" data-url="https://findermp.video.qq.com/251/20304/stodownload?encfilekey=S7s6ianIic0ia4PicKJSfB8EjyjpQibPUAXolXibL68d59PuA8FEAXlcXVOdK0uKM6cnrs0rc8KbUy0OGoN6DS0wBGWxFB0BTSyQ26wF2pWpIPHSW13jlAMg2BlQ&adaptivelytrans=0&bizid=1023&dotrans=0&hy=SH&idx=1&m=&scene=0&token=AxricY7RBHdUMsTOKMOFwib0ByulpuvnAd5whTezlDBAtDZJ3yQ8WfeAMGYwG6JjWadEMSHp6qyfo" data-headimgurl="http://wx.qlogo.cn/finderhead/Q3auHgzwzM7XvIaJWDhiackadhCGhkqvYzIK8hv5vV19Rq0blMIJfJw/0" data-username="v2_060000231003b20faec8c5e18b1ac4dccb07ea30b0772e253ae5600e19a6daeb23a9ea18f52d@finder" data-nickname="生物制品圈" data-desc="关于疫苗的基本知识和疫苗分类_(What_is_a_Vaccine_）" data-nonceid="3766298452096353051" data-type="video" data-width="1280" data-height="720"></mpvideosnap></section>
</div>
页:
[1]